Diffuse diabetic macular oedema treated by intravitreal triamcinolone acetonide: a comparative, non-randomised study.
نویسندگان
چکیده
AIM To report on visual outcome of patients receiving an intravitreal injection of triamcinolone acetonide for treatment of diffuse diabetic macular oedema. METHODS Prospective, comparative, non-randomised clinical interventional study included 136 patients with diffuse diabetic macular oedema. Patients of the study group (97 eyes) received an intravitreal injection of 20-25 mg of triamcinolone acetonide and no other retinal treatment. Patients of the control group (69 eyes) received focal or panretinal laser treatment if indicated. Mean (standard deviation) follow up was 8.4 (SD 6.0) months (range 1.03-25.2 months). RESULTS Visual acuity (VA) increased significantly (p<0.001) in the study group with 66 (68%) eyes gaining in VA by at least two Snellen lines. In the control group, VA did not change significantly during the first 4 months of follow up, and decreased significantly (p<0.001) towards the end of the follow up. Difference in change of best VA was significant (p<0.001) between both groups. Correspondingly, the number of patients with VA improvement of two or more Snellen lines and visual loss of two or more Snellen lines, respectively, was significantly (p<0.001) higher and lower, respectively, in the study group. CONCLUSIONS Intravitreal triamcinolone acetonide can temporarily increase VA in some patients with diffuse diabetic macular oedema.
منابع مشابه
Dosage dependency of intravitreal triamcinolone acetonide as treatment for diabetic macular oedema.
AIM To evaluate the effect of different doses of intravitreal triamcinolone acetonide on diffuse diabetic macular oedema. METHODS The prospective, randomised, double masked, clinical interventional study included 27 eyes (27 patients) with diffuse diabetic macular oedema. They were randomly divided into three study groups receiving an intravitreal injection of filtered triamcinolone acetonide...
متن کاملIntravitreal versus sub-Tenon triamcinolone acetonide for refractory diffuse diabetic macular oedema
متن کامل
Effect of Intravitreal Triamcinolone Acetonide on Improvement of Visual Acuity and Resolution of Diffuse Diabetic Macular Oedema
Subclinical inflammation occurring in diabetic retinopathy is supposed to be, at least partly, the cause of breakage of blood-retinal barrier. It may be expected that anti-inflammatory drugs have favorable effect on the course of diabetic macular oedema. The aim was to investigate the effect of intravitreally applied triamcinolone acetonide (TA) on resolution of diffuse diabetic macular oedema ...
متن کاملIntravitreal triamcinolone acetonide for the treatment of diffuse diabetic macular oedema--a case report.
INTRODUCTION Although laser photocoagulation is the primary treatment for diabetic macular oedema, treatment of eyes with diffuse macular oedema has been disappointing. Intravitreal injection of steroids is being investigated for the treatment of diabetic macular oedema. Preliminary results indicate that steroid injections do improve macular oedema, but it is not clear if they improve visual ac...
متن کاملDose Dependent Effects of Intravitreal Triamcinolone Acetonide on Diffuse Diabetic Macular Edema
PURPOSE To evaluate the effect of different doses of intravitreal triamcinolone acetonide on diffuse diabetic macular edema. METHODS In a retrospective study, 44 eyes with diffuse diabetic macular edema were treated with an intravitreal injection of 4 mg (n=12 eyes), 8 mg (n=17) or 25 mg (n=15) of triamcinolone acetonide (TA). Optical coherence tomography, best-corrected logMAR visual acuity ...
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عنوان ژورنال:
- The British journal of ophthalmology
دوره 89 3 شماره
صفحات -
تاریخ انتشار 2005